Α-glucosidase and Chymotrypsin Inhibiting Lignans from Commiphora Mukul
نویسندگان
چکیده
Phytochemical investigation of the whole plant of Commiphora mukul Engl. resulted in the isolation of two lignans, epiexcelsin (1) and 5′-demethoxyepiexcelsin (2) which are reported for the first time from this species. The structure elucidation of the isolated compounds was based on 1D and 2DNMR analysis and by the comparison with the published data. The lignans 1 and 2 showed significant inhibitory activity against α-glucosidase with the IC 50 of 59.8 ± 3.63455 μM and 75.2 ± 8.1616 μM respectively. They also showed weak inhibitory potential against chymotrypsin with the IC 50 of 110 ± 0.025 μM and 649 ± 0.013 μM respectively.
منابع مشابه
Pharmacology and Phytochemistry of Oleo-Gum Resin of Commiphora wightii (Guggulu)
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